Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-6-7
pubmed:abstractText
Optical fiber-based mapping systems are used to record the cardiac action potential (AP) throughout the myocardium. The optical AP contains a contraction-induced motion artifact (MA), which makes it difficult to accurately measure the action potential duration (APD). MA is removed by preventing contraction with electrical-mechanical uncoupling drugs, such as 2,3-butanedione monoxime (BDM). We designed a novel fiber-based ratiometric optical channel using a blue light emitting diode, a diffraction grating, and a split photodetector that can accurately measure the cardiac AP without the need for BDM. The channel was designed based on simulations using the optical design software ZEMAX. The channel has an electrical bandwidth of 150 Hz and an root mean-square dark noise of 742 muV. The channel successfully recorded the cardiac AP from the wall of five rabbit heart preparations without the use of BDM. After 20-point median filtering, the mean signal/noise ratio was 25.3 V/V. The APD measured from the base of a rabbit heart was 134 +/- 8.4 ms, compared to 137.6 +/- 3.3 ms from simultaneous microelectrode recordings. This difference was not statistically significant (p-value = 0.3). The quantity of MA removed was also measured using the motion ratio. The reduction in MA was significant (p-value = 0.0001). This fiber-based system is the first of its kind to enable optical APD measurements in the beating heart wall without the use of BDM.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-10096922, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-10700444, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-10833699, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-10993810, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-11356625, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-11606280, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-12475106, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-12679330, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-14678134, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-1469705, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-14765706, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-15130885, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-15191898, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-15455771, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-16174023, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-16916108, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-17122194, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-1873877, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-1911828, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-1934358, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-2036721, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-2352836, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-2765500, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-3156242, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-4084490, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-6243361, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-7227454, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-8087954, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-8930734, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-9255686, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-9665060, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-9675208, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-9869533, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-9869534, http://linkedlifedata.com/resource/pubmed/commentcorrection/17416627-9869535
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
254-63
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
A fiber-based ratiometric optical cardiac mapping channel using a diffraction grating and split detector.
pubmed:affiliation
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA. ninita.brown@duke.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural