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rdf:type |
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lifeskim:mentions |
umls-concept:C0023690,
umls-concept:C0033554,
umls-concept:C0034929,
umls-concept:C0037941,
umls-concept:C0458247,
umls-concept:C0521329,
umls-concept:C0871261,
umls-concept:C1511545,
umls-concept:C1527148,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
2007-4-6
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pubmed:abstractText |
Spinal prostaglandins are important in the early pathogenesis of spinal nerve ligation (SNL)-induced allodynia. This study examined the effect of SNL on the expression of cyclooxygenase (COX)-1, COX-2, and prostaglandin E2 receptors in the rat lumbar spinal cord, and the temporal and pharmacologic relation of these changes to the exaggerated A- and C-fiber-mediated reflex responses and allodynia, 24 h after injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(5-(4-chlorophenyl)-3-(trifluorome...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP1...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP2...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP3...,
http://linkedlifedata.com/resource/pubmed/chemical/SC 560,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
795-805
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17413918-Animals,
pubmed-meshheading:17413918-Cyclooxygenase 1,
pubmed-meshheading:17413918-Injections, Spinal,
pubmed-meshheading:17413918-Ligation,
pubmed-meshheading:17413918-Male,
pubmed-meshheading:17413918-Nerve Fibers, Myelinated,
pubmed-meshheading:17413918-Nerve Fibers, Unmyelinated,
pubmed-meshheading:17413918-Pain,
pubmed-meshheading:17413918-Prostaglandins,
pubmed-meshheading:17413918-Pyrazoles,
pubmed-meshheading:17413918-Rats,
pubmed-meshheading:17413918-Rats, Sprague-Dawley,
pubmed-meshheading:17413918-Receptors, Prostaglandin E,
pubmed-meshheading:17413918-Receptors, Prostaglandin E, EP1 Subtype,
pubmed-meshheading:17413918-Receptors, Prostaglandin E, EP2 Subtype,
pubmed-meshheading:17413918-Receptors, Prostaglandin E, EP3 Subtype,
pubmed-meshheading:17413918-Reflex,
pubmed-meshheading:17413918-Spinal Nerves,
pubmed-meshheading:17413918-Sulfonamides
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pubmed:year |
2007
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pubmed:articleTitle |
Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation.
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pubmed:affiliation |
Division of Basic Medical Sciences, School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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