|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0243076,
umls-concept:C0441655,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C1412113,
umls-concept:C1704689,
umls-concept:C1873145,
umls-concept:C1883254
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|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2007-4-30
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|
pubmed:abstractText |
A series of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety were synthesized and evaluated as a novel class of AT(1) receptor antagonists. Among them, compounds 10a and 10g inhibited [(125)I] AngII-binding affinity to AT(1) receptor at nanomolar level and potently inhibited the Ang II-induced pressor response by oral administration. Moreover, evaluation in spontaneously hypertensive rats showed that 10a is an orally active AT(1) receptor antagonist.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
May
|
|
pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:HeQian HuiQH,
pubmed-author:HuSongS,
pubmed-author:HuaWei YiWY,
pubmed-author:LuWuW,
pubmed-author:RanQianQ,
pubmed-author:TangMing YueMY,
pubmed-author:WangQiu JuanQJ,
pubmed-author:WuXiao MingXM,
pubmed-author:XuJin YiJY,
pubmed-author:ZengYiY,
pubmed-author:ZhangJingJ,
pubmed-author:ZhenWeiW
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2921-6
|
|
pubmed:meshHeading |
pubmed-meshheading:17412584-Administration, Oral,
pubmed-meshheading:17412584-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:17412584-Animals,
pubmed-meshheading:17412584-Models, Molecular,
pubmed-meshheading:17412584-Molecular Structure,
pubmed-meshheading:17412584-Rats,
pubmed-meshheading:17412584-Rats, Inbred SHR,
pubmed-meshheading:17412584-Structure-Activity Relationship
|
|
pubmed:year |
2007
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|
pubmed:articleTitle |
Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists.
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|
pubmed:affiliation |
Department of Medicinal Chemistry, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China. jinyixu@china.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
