Source:http://linkedlifedata.com/resource/pubmed/id/17410466
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2007-10-2
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pubmed:abstractText |
Liver biopsy was until recently the only way of evaluating liver fibrosis. Noninvasive tests for hepatic fibrosis, without potential risks, are desired by clinicians as well as patients. Insulin-like growth factor-I (IGF-I) synthesis is disturbed in liver fibrosis and reflects the severity of the clinical stage. We assessed serum IGF-I levels in patients with chronic hepatitis C (CHC) to correlate with liver fibrosis and antiviral therapy. Forty patients with CHC and persistently abnormal alanine aminotransferase values were enrolled and treated with peginterferon alpha-2a 180 microg per week plus ribavirin for 24 (n=20) or 48 (n=20) weeks. All patients underwent liver biopsy before treatment (METAVIR fibrosis stage F0, n=13; F1-F2, n=14; F3, n=7; F4, n=6). Serum IGF-I was measured at baseline, at the end of treatment period, and 24 weeks after finishing treatment. Mean IGF-I values were significantly lower in patients with advanced fibrosis (F4, 65.9+/-17.9 ng/mL) than in the others (F0, 145.2+/-47.1; F1-F2, 150.3+/-89.6; and F3, 121.4+/-35.2 ng/mL; P < .05). Serum IGF-I levels increased during combined therapy, being this increment markedly higher in patients with sustained virologic response. In conclusion, IGF-I synthesis is disturbed in CHC and reflects the severity of the liver fibrosis. Combined therapy improves serum IGF-I levels. IGF-I could represent a good, noninvasive marker of liver fibrosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0163-2116
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3245-50
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pubmed:dateRevised |
2008-1-24
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pubmed:meshHeading |
pubmed-meshheading:17410466-Adult,
pubmed-meshheading:17410466-Antiviral Agents,
pubmed-meshheading:17410466-Biological Markers,
pubmed-meshheading:17410466-Biopsy,
pubmed-meshheading:17410466-Female,
pubmed-meshheading:17410466-Follow-Up Studies,
pubmed-meshheading:17410466-Hepacivirus,
pubmed-meshheading:17410466-Hepatitis C, Chronic,
pubmed-meshheading:17410466-Humans,
pubmed-meshheading:17410466-Immunoassay,
pubmed-meshheading:17410466-Insulin-Like Growth Factor I,
pubmed-meshheading:17410466-Liver Cirrhosis,
pubmed-meshheading:17410466-Male,
pubmed-meshheading:17410466-Middle Aged,
pubmed-meshheading:17410466-Prognosis,
pubmed-meshheading:17410466-Prospective Studies,
pubmed-meshheading:17410466-RNA, Viral
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pubmed:year |
2007
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pubmed:articleTitle |
Serum concentrations of insulin-like growth factor-I (igf-I) as a marker of liver fibrosis in patients with chronic hepatitis C.
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pubmed:affiliation |
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916, Badalona, Barcelona, Spain. vlorenzo@ns.hugtip.scs.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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