Linked Life Data

1741019

Source:http://linkedlifedata.com/resource/pubmed/id/1741019

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-3-24
pubmed:abstractText
The role of calcium in the invasion of human erythrocytes by Plasmodium falciparum merozoites has been investigated using a variety of techniques. It has been demonstrated using calcium-depleted medium that invasion is dependent upon the presence of calcium and that neither magnesium, manganese or zinc may substitute for it, suggesting that the effect is calcium specific and not dependent upon a non-specific, charge-based mechanism. Using resealed erythrocyte ghosts and altering the internal and external concentrations of calcium and the chelator EGTA, it has been shown that the role of calcium in invasion, at least as far as the target cell is concerned, is in the extracellular environment. Similarly, loading either the schizont-infected, or target erythrocyte with the membrane permeant calcium chelator Indo-1, at concentrations sufficient to chelate approximately 100 times the concentration of resting cell calcium, produced no change in the parasite invasion rate. Consequently we conclude that calcium plays an extra-cellular role in merozoite invasion of the human erythrocyte.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0166-6851
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-23
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
The role of calcium in the invasion of human erythrocytes by Plasmodium falciparum.
pubmed:affiliation
Division of Parasitology, National Institute for Medical Research, London, U.K.
pubmed:publicationType
Journal Article