Linked Life Data

17409471

Source:http://linkedlifedata.com/resource/pubmed/id/17409471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-4-5
pubmed:abstractText
A number of biomedical devices require extended electrical communication with surrounding tissue. Significant improvements in device performance would be achieved if it were possible to maintain communication with target cells despite the reactive, insulating scar tissue that forms at the device-tissue interface. Here, we report that the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) can be polymerized directly within living neural tissue resulting in an electrically conductive network that is integrated within the tissue. Nano and microscale PEDOT filaments extend out from electrode sites, presumably forming within extracellular spaces. The cloud of PEDOT filaments penetrates out into the tissue far enough that it should be possible to bypass fibrous scar tissue and contact surrounding healthy neurons. These electrically functional, diffuse conducting polymer networks grown directly within tissue signify a new paradigm for creating soft, low impedance implantable electrodes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1741-2560
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
L6-L13
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Electrochemical polymerization of conducting polymers in living neural tissue.
pubmed:affiliation
Regenerative Sciences Program, University of Michigan, Ann Arbor, MI 48109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, N.I.H., Extramural