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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-4-30
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pubmed:abstractText |
The Forkhead box gene, group O (FoxO) family of Forkhead transcription factors is phopsphorylated and inactivated by the phosphatidylinositol 3-kinase (PI3K)/AKT pathway and regulates a variety of cellular functions. Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. A fibrotic stimulus causes HSCs to transdifferentiate from a quiescent phenotype to a collagen-producing myofibroblast-like phenotype and to proliferate.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxo1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Foxo1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pik3cd protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor A
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1434-46
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17408630-Animals,
pubmed-meshheading:17408630-Blotting, Western,
pubmed-meshheading:17408630-Cell Differentiation,
pubmed-meshheading:17408630-Cell Proliferation,
pubmed-meshheading:17408630-Cells, Cultured,
pubmed-meshheading:17408630-Chromones,
pubmed-meshheading:17408630-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:17408630-Enzyme Inhibitors,
pubmed-meshheading:17408630-Forkhead Transcription Factors,
pubmed-meshheading:17408630-Gene Expression Regulation,
pubmed-meshheading:17408630-Hepatocytes,
pubmed-meshheading:17408630-Hypoglycemic Agents,
pubmed-meshheading:17408630-Insulin,
pubmed-meshheading:17408630-Liver Cirrhosis, Experimental,
pubmed-meshheading:17408630-Male,
pubmed-meshheading:17408630-Mice,
pubmed-meshheading:17408630-Mice, Inbred BALB C,
pubmed-meshheading:17408630-Microscopy, Fluorescence,
pubmed-meshheading:17408630-Morpholines,
pubmed-meshheading:17408630-Nerve Tissue Proteins,
pubmed-meshheading:17408630-Phenotype,
pubmed-meshheading:17408630-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:17408630-Phosphorylation,
pubmed-meshheading:17408630-Platelet-Derived Growth Factor,
pubmed-meshheading:17408630-RNA,
pubmed-meshheading:17408630-Rats,
pubmed-meshheading:17408630-Rats, Sprague-Dawley,
pubmed-meshheading:17408630-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17408630-Superoxide Dismutase,
pubmed-meshheading:17408630-Translocation, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.
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pubmed:affiliation |
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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