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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-4-4
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pubmed:abstractText |
A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1477-0520
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1218-27
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17406720-Carbazoles,
pubmed-meshheading:17406720-Crystallography, X-Ray,
pubmed-meshheading:17406720-Ligands,
pubmed-meshheading:17406720-Models, Molecular,
pubmed-meshheading:17406720-Molecular Structure,
pubmed-meshheading:17406720-Organometallic Compounds,
pubmed-meshheading:17406720-Protein Kinase Inhibitors,
pubmed-meshheading:17406720-Protein Kinases,
pubmed-meshheading:17406720-Ruthenium,
pubmed-meshheading:17406720-Stereoisomerism,
pubmed-meshheading:17406720-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand.
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pubmed:affiliation |
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA. meggers@sas.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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