17406677

Source:http://linkedlifedata.com/resource/pubmed/id/17406677

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003320, umls-concept:C0007613, umls-concept:C0039194, umls-concept:C0041361, umls-concept:C0079189, umls-concept:C0812222, umls-concept:C1510996, umls-concept:C1704410, umls-concept:C2603343
pubmed:issue	4
pubmed:dateCreated	2007-4-4
pubmed:abstractText	Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the function of TAA-specific T cells.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101285081
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Mdm2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2
pubmed:status	MEDLINE
pubmed:issn	1932-6203
pubmed:author	pubmed-author:BendleGavin MGM, pubmed-author:HollerAngelikaA, pubmed-author:StaussHans JHJ, pubmed-author:XueShao-AnSA
pubmed:issnType	Electronic
pubmed:volume	2
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	e353
pubmed:meshHeading	pubmed-meshheading:17406677-Animals, pubmed-meshheading:17406677-Antibody Affinity, pubmed-meshheading:17406677-Base Sequence, pubmed-meshheading:17406677-Cell Differentiation, pubmed-meshheading:17406677-Cell Proliferation, pubmed-meshheading:17406677-Cytokines, pubmed-meshheading:17406677-DNA Primers, pubmed-meshheading:17406677-Flow Cytometry, pubmed-meshheading:17406677-Immune Tolerance, pubmed-meshheading:17406677-Mice, pubmed-meshheading:17406677-Mice, Transgenic, pubmed-meshheading:17406677-Polymerase Chain Reaction, pubmed-meshheading:17406677-Proto-Oncogene Proteins c-mdm2, pubmed-meshheading:17406677-T-Lymphocytes, Cytotoxic
pubmed:year	2007
pubmed:articleTitle	A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell function.
pubmed:affiliation	Centre de Recherche Public-Santé, Luxembourg.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't