Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2007-8-1
pubmed:abstractText
Growing evidence indicates that adenosine receptors could be promising therapeutic targets in autoimmune diseases. Here we studied the role of adenosine receptors in controlling the course of type 1 diabetes. Diabetes in CD-1 mice was induced by multiple-low-dose-streptozotocin (MLDS) treatment and in nonobese diabetic (NOD) mice by cyclophosphamide injection. The nonselective adenosine receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA) prevented diabetes development in both MLDS-challenged mice and in cyclophosphamide-treated NOD mice. The effect of NECA was reversed by the selective A2B receptor antagonist N-(4-cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide (MRS 1754). The selective A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and A3 receptor agonist N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (IB-MECA) were less efficacious in ameliorating the course of diabetes. NECA inhibited diabetes in A2A receptor KO mice and the selective A2A receptor agonist 2-p-(2-carboxyethyl)phenethyl-amino-5'-N-ethyl-carboxamidoadenosine (CGS21680) had no effect in normal mice, indicating a lack of role of A2A receptors. NECA failed to prevent cytokine-induced beta-cell death in vitro, but NECA strongly suppressed expression of the proinflammatory cytokines TNF-alpha, MIP-1alpha, IL-12, and IFN-gamma in pancreata, endotoxin, or anti-CD3-stimulated splenic cells, and T helper 1 lymphocytes, indicating that the beneficial effect of NECA was due to immunomodulation. These results demonstrate that adenosine receptor ligands are potential candidates for the treatment of type 1 diabetes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-10092821, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-10599690, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-10694196, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-10878389, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-10933149, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-11023991, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-11564822, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-11734617, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-11780065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-12117305, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-12865945, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-12939345, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-1460428, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-14698282, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-14960625, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-15032592, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-15229371, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-15583013, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-15634932, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-16012931, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-16339566, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-16339914, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-16622031, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-16823489, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-17192471, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-1909135, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-2163307, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-6480196, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-6605314, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-8906843, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9262401, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9325320, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9443164, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9679667, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9719467, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9755289, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9786512, http://linkedlifedata.com/resource/pubmed/commentcorrection/17405852-9914161
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1530-6860
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2379-88
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Adenosine receptor activation ameliorates type 1 diabetes.
pubmed:affiliation
Department of Surgery, UMDNJ-New Jersey Medical School, 185 South Orange Ave., University Heights, Newark, NJ 07103, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural