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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2007-4-11
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pubmed:abstractText |
COUP-TFII (NR2F2), chicken ovalbumin upstream promoter-transcription factor II, is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily. The Coup-tfII-null mutant mice die during the early embryonic development because of angiogenesis and heart defects. To analyze the physiological function of COUP-TFII during organogenesis, we used the cre/loxP system to conditionally inactivate COUP-TFII in the ovary and uterus. Homozygous adult female mutants with specific inactivation of the Coup-tfII gene in uterine stromal and smooth muscle cells have severely impaired placental formation, leading to miscarriage at days 10-12 of pregnancy. Deletion of the Coup-tfII gene resulted in an increase in trophoblast giant cell differentiation, a reduction of the spongiotrophoblast layer, and an absence of labyrinth formation causing an improper vascularization of the placenta. This study describes an important maternal role of COUP-TFII in regulating the placentation. The endometrial COUP-TFII might modulate the signaling between the uterus and the extraembryonic tissue for the proper formation of the placenta.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-10215630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-10624948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-11416163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-11433360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-11437448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-11511537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-12368913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-12554639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-1342960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-14738874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-15572686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-15708112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-15837063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-15890675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-15963972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-2644044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-3047555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-3215514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-790515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-7979245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-8521507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-9101138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-9271116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-9285590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17404209-9460643
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6293-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17404209-Animals,
pubmed-meshheading:17404209-COUP Transcription Factor II,
pubmed-meshheading:17404209-Cell Differentiation,
pubmed-meshheading:17404209-Female,
pubmed-meshheading:17404209-Gene Silencing,
pubmed-meshheading:17404209-Giant Cells,
pubmed-meshheading:17404209-Immunohistochemistry,
pubmed-meshheading:17404209-In Situ Hybridization,
pubmed-meshheading:17404209-Mice,
pubmed-meshheading:17404209-Ovary,
pubmed-meshheading:17404209-Placenta Diseases,
pubmed-meshheading:17404209-Placentation,
pubmed-meshheading:17404209-Pregnancy,
pubmed-meshheading:17404209-Trophoblasts,
pubmed-meshheading:17404209-Uterus
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pubmed:year |
2007
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pubmed:articleTitle |
Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. fabrice.petit@u-psud.fr [corrected]
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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