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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-4-3
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pubmed:abstractText |
Insulin-like growth factor binding protein-3 (IGFBP-3) is a well-known antiproliferative and proapoptotic molecule in prostate cancer, suggesting that targeting IGFBP-3 might produce clinical benefits. In prostate cancer cells, RRR-alpha-vitamin E succinate (VES) inhibits cell proliferation and induces apoptosis, yet the mechanisms remain to be elucidated. We hypothesize that the protective effects of VES in prostate cancer are mediated by IGFBP-3 up-regulation. Using prostate cancer models, the involvement of IGFBP-3 in the anticancer effect of VES was investigated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2271-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17404112-Animals,
pubmed-meshheading:17404112-Antineoplastic Agents,
pubmed-meshheading:17404112-Apoptosis,
pubmed-meshheading:17404112-Blotting, Western,
pubmed-meshheading:17404112-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17404112-Humans,
pubmed-meshheading:17404112-Immunohistochemistry,
pubmed-meshheading:17404112-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:17404112-Male,
pubmed-meshheading:17404112-Mice,
pubmed-meshheading:17404112-Mice, Nude,
pubmed-meshheading:17404112-Mice, Transgenic,
pubmed-meshheading:17404112-Prostatic Neoplasms,
pubmed-meshheading:17404112-RNA, Messenger,
pubmed-meshheading:17404112-RNA, Small Interfering,
pubmed-meshheading:17404112-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17404112-Tocopherols,
pubmed-meshheading:17404112-Vitamin E
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pubmed:year |
2007
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pubmed:articleTitle |
The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostate cancer via induction of insulin-like growth factor binding protein-3.
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pubmed:affiliation |
Department of Urology , George Whipple Laboratory for Cancer Research, University of Rochester, Rochester, New York 14642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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