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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-7-23
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pubmed:abstractText |
Vgamma9/Vdelta2 (gammadelta) T cells play a major role in innate immunity against microbes, stressed, and tumor cells. They represent less than 5% of peripheral blood lymphocytes but can be activated and expanded in vitro by aminobisphosphonates (ABP)-treated monocytes. The aim of this work was to determine whether ABP-treated dendritic cells (DCs) can also activate gammadelta T cells and regulate immune responses mediated by conventional alphabeta T cells. Highly purified immature (iDC) and mature DC (mDC) were generated from peripheral blood monocytes of healthy donors and incubated with zoledronic acid (Zol) for 24 hours. Zol-treated iDC and mDC retained their immunostimulatory properties and induced the vigorous expansion of central memory and effector memory gammadelta T cells. gammadelta T cells displayed antitumor activity and appropriate cell surface antigens to target secondary lymphoid organs and exert costimulatory activity. Antigen-specific MHC-restricted immune responses, mediated by conventional alphabeta T cells, were improved by the concurrent gammadelta T-cell activation. In conclusion, large numbers of gammadelta T cells with effector and costimulatory activities are rapidly generated by Zol-treated iDC/mDC. This strategy is worthy of further investigation to improve adoptive cell therapy and vaccine interventions against tumors and infections.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Density Conservation Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Diphosphonates,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/zoledronic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
921-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17403919-Adjuvants, Immunologic,
pubmed-meshheading:17403919-Bone Density Conservation Agents,
pubmed-meshheading:17403919-Cancer Vaccines,
pubmed-meshheading:17403919-Cell Proliferation,
pubmed-meshheading:17403919-Cells, Cultured,
pubmed-meshheading:17403919-Dendritic Cells,
pubmed-meshheading:17403919-Diphosphonates,
pubmed-meshheading:17403919-Histocompatibility Antigens,
pubmed-meshheading:17403919-Humans,
pubmed-meshheading:17403919-Imidazoles,
pubmed-meshheading:17403919-Immunity, Innate,
pubmed-meshheading:17403919-Immunologic Memory,
pubmed-meshheading:17403919-Immunotherapy, Adoptive,
pubmed-meshheading:17403919-Lymphocyte Activation,
pubmed-meshheading:17403919-Monocytes,
pubmed-meshheading:17403919-Neoplasms,
pubmed-meshheading:17403919-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:17403919-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:17403919-T-Lymphocytes,
pubmed-meshheading:17403919-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid.
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pubmed:affiliation |
Division of Hematology, University of Turin, Via Genova 3, 10126 Turin, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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