| pubmed-article:17403873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17403873 | lifeskim:mentions | umls-concept:C0851886 | lld:lifeskim |
| pubmed-article:17403873 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:17403873 | lifeskim:mentions | umls-concept:C1522496 | lld:lifeskim |
| pubmed-article:17403873 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:17403873 | lifeskim:mentions | umls-concept:C0963088 | lld:lifeskim |
| pubmed-article:17403873 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:17403873 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17403873 | pubmed:dateCreated | 2007-5-21 | lld:pubmed |
| pubmed-article:17403873 | pubmed:abstractText | Host defense mechanisms against Pneumocystis carinii are not fully understood. Previous work in the murine model has shown that host defense against infection is critically dependent upon host CD4(+) T cells. The recently described Th17 immune response is predominantly a function of effector CD4(+) T cells stimulated by interleukin-23 (IL-23), but whether these cells are required for defense against P. carinii infection is unknown. We tested the hypothesis that P. carinii stimulates the early release of IL-23, leading to increases in IL-17 production and lung effector CD4(+) T-cell population that mediate clearance of infection. In vitro, stimulation of alveolar macrophages with P. carinii induced IL-23, and IL-23p19 mRNA was expressed in lungs of mice infected with this pathogen. To address the role of IL-23 in resistance to P. carinii, IL-23p19-/- and wild-type control C57BL/6 mice were infected and their fungal burdens and cytokine/chemokine responses were compared. IL-23p19-/- mice displayed transient but impaired clearance of infection, which was most apparent 2 weeks after inoculation. In confirmatory studies, the administration of either anti-IL-23p19 or anti-IL-17 neutralizing antibody to wild-type mice infected with P. carinii also caused increases in fungal burdens. IL-17 and the lymphocyte chemokines IP-10, MIG, MIP-1alpha, MIP-1beta, and RANTES were decreased in the lungs of infected IL-23p19-/- mice in comparison to their levels in the lungs of wild-type mice. In IL-23p19-/- mice infected with P. carinii, there were fewer effector CD4(+) T cells in the lung tissue. Collectively, these studies indicate that the IL-23-IL-17 axis participates in host defense against P. carinii. | lld:pubmed |
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| pubmed-article:17403873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17403873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17403873 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17403873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17403873 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17403873 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:17403873 | pubmed:author | pubmed-author:RudnerXiaowen... | lld:pubmed |
| pubmed-article:17403873 | pubmed:author | pubmed-author:ShellitoJudd... | lld:pubmed |
| pubmed-article:17403873 | pubmed:author | pubmed-author:HappelKyle... | lld:pubmed |
| pubmed-article:17403873 | pubmed:author | pubmed-author:YoungErana... | lld:pubmed |
| pubmed-article:17403873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17403873 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:17403873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17403873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17403873 | pubmed:pagination | 3055-61 | lld:pubmed |
| pubmed-article:17403873 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17403873 | pubmed:meshHeading | pubmed-meshheading:17403873... | lld:pubmed |
| pubmed-article:17403873 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17403873 | pubmed:articleTitle | Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. | lld:pubmed |
| pubmed-article:17403873 | pubmed:affiliation | Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA. | lld:pubmed |
| pubmed-article:17403873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17403873 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:83430 | entrezgene:pubmed | pubmed-article:17403873 | lld:entrezgene |
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