|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2007-4-3
|
|
pubmed:abstractText |
Labor is associated with 'decidual activation' with increased proteolysis and extracellular matrix degradation. The balance between plasminogen activator inhibitor-1 (PAI-1) and urokinase (uPA) and tissue-type plasminogen activator (tPA) is an important determinant of proteolytic activity at the maternal-fetal interface. Thrombin released at the time of placental abruption (decidual hemorrhage) is known to promote decidual proteolysis and uterine contractions. This study investigates the separate and interactive effects of steroid hormones and thrombin on PAI-1, uPA, and tPA expression by term decidual cells (DCs).
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1097-6868
|
|
pubmed:author |
pubmed-author:BuchwalderLynnL,
pubmed-author:BuhimschiCatalin SCS,
pubmed-author:BuhimschiIrina AIA,
pubmed-author:FoyouziNastaranN,
pubmed-author:FunaiEdmund FEF,
pubmed-author:LeeHee JoongHJ,
pubmed-author:LockwoodCharles JCJ,
pubmed-author:NorwitzErrol RER,
pubmed-author:RahmanMizanurM,
pubmed-author:SchatzFrederickF,
pubmed-author:SnegovskikhVictoriaV
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
196
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
382.e1-8
|
|
pubmed:dateRevised |
2007-12-3
|
|
pubmed:meshHeading |
pubmed-meshheading:17403427-Blotting, Western,
pubmed-meshheading:17403427-Cells, Cultured,
pubmed-meshheading:17403427-Decidua,
pubmed-meshheading:17403427-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17403427-Female,
pubmed-meshheading:17403427-Humans,
pubmed-meshheading:17403427-Parturition,
pubmed-meshheading:17403427-Plasminogen Activators,
pubmed-meshheading:17403427-Plasminogen Inactivators,
pubmed-meshheading:17403427-Pregnancy,
pubmed-meshheading:17403427-Pregnancy Trimester, Third,
pubmed-meshheading:17403427-Probability,
pubmed-meshheading:17403427-Progestins,
pubmed-meshheading:17403427-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17403427-Sampling Studies,
pubmed-meshheading:17403427-Sensitivity and Specificity,
pubmed-meshheading:17403427-Statistics, Nonparametric,
pubmed-meshheading:17403427-Stromal Cells,
pubmed-meshheading:17403427-Thrombin
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition.
|
|
pubmed:affiliation |
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520-8063, USA. errol.norwitz@yale.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
