Source:http://linkedlifedata.com/resource/pubmed/id/17402372
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-4-3
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pubmed:abstractText |
The aim of this study was to describe the clinical manifestations and outcomes of a national cohort of childhood systemic lupus erythematosus (cSLE). All cases of cSLE registered in the Israeli national registry of children with rheumatic diseases between 1987-2003 were examined for disease activity and damage by the SLE disease activity index (SLEDAI) and SLE collaborating clinics/American College of Rheumatology (SLICC/ACR) damage index. Demographic, clinical, laboratory and treatment factors were analysed for their effect on the outcome. One-hundred and two patients were identified, 81% females, with a mean age at diagnosis of 13.3 +/- 2.6 years. The mean SLEDAI score was 17.2 +/- 9.0 (range 2-60). Fifty four patients were followed for at least five years. The mean SLEDAI decreased to 7.6 +/- 6.3 (0-29) and the mean SLICC/ACR damage index was 0.7 +/- 1.6 (0-8). Five patients developed chronic renal failure. No patients died. No factors were found to be significantly associated with the outcome except the initial SLEDAI score. The five-year outcome of our national cSLE cohort was good; with relatively low activity and minimal damage in most patients. The initial SLEDAI predicted the development of late damage.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0961-2033
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pubmed:author |
pubmed-author:BarashJJ,
pubmed-author:BerkusVV,
pubmed-author:BrikRR,
pubmed-author:GorodnitskiNN,
pubmed-author:HarelLL,
pubmed-author:HashkesP JPJ,
pubmed-author:MevorachDD,
pubmed-author:MukamelMM,
pubmed-author:NaparstekYY,
pubmed-author:NavonPP,
pubmed-author:PadehSS,
pubmed-author:Pediatric Rheumatology Study Group Of Israel @ SLERI,
pubmed-author:PressJJ,
pubmed-author:RubensteinMM,
pubmed-author:TauberTT,
pubmed-author:UzielYY
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
142-6
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pubmed:meshHeading |
pubmed-meshheading:17402372-Adolescent,
pubmed-meshheading:17402372-Child,
pubmed-meshheading:17402372-Female,
pubmed-meshheading:17402372-Follow-Up Studies,
pubmed-meshheading:17402372-Humans,
pubmed-meshheading:17402372-Israel,
pubmed-meshheading:17402372-Lupus Erythematosus, Systemic,
pubmed-meshheading:17402372-Male,
pubmed-meshheading:17402372-Registries
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pubmed:year |
2007
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pubmed:articleTitle |
Outcome of a national Israeli cohort of pediatric systemic lupus erythematosus.
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pubmed:affiliation |
Department of Pediatrics, Meir Medical Center, Tel Aviv University Kfar-Saba, Isreal. uziely@zahav.net.il
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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