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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-26
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pubmed:abstractText |
Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:AbenKatja KKK,
pubmed-author:AgnarssonBjarni ABA,
pubmed-author:Albers-AkkersMarjo TMT,
pubmed-author:AmundadottirLaufey TLT,
pubmed-author:BackmanValgerdur MVM,
pubmed-author:BakerAdamA,
pubmed-author:BarkardottirRosa BRB,
pubmed-author:BenediktsdottirKristrun RKR,
pubmed-author:BergthorssonJon TJT,
pubmed-author:BlondalThorarinnT,
pubmed-author:CashyJohnJ,
pubmed-author:CatalonaWilliam JWJ,
pubmed-author:EinarssonGudmundur VGV,
pubmed-author:FriggeMikeM,
pubmed-author:GhoshShyamaliS,
pubmed-author:Godino-Ivan MarcosJavierJ,
pubmed-author:GraifTheresaT,
pubmed-author:GudbjartssonDanielD,
pubmed-author:GudmundssonJuliusJ,
pubmed-author:GulcherJeffrey RJR,
pubmed-author:HelgasonAgnarA,
pubmed-author:IsaacsSarah DSD,
pubmed-author:IsaacsWilliam BWB,
pubmed-author:JakobsdottirMargretM,
pubmed-author:JonssonEirikurE,
pubmed-author:KiemeneyLambertus ALA,
pubmed-author:KongAugustineA,
pubmed-author:KosticJelenaJ,
pubmed-author:KristjanssonKristleifurK,
pubmed-author:ManolescuAndreiA,
pubmed-author:MayordomoJose IJI,
pubmed-author:MouyMagaliM,
pubmed-author:NavarreteSebastianS,
pubmed-author:OberCaroleC,
pubmed-author:PartinAlan WAW,
pubmed-author:RafnarThorunnT,
pubmed-author:Ruiz-EcharriManuelM,
pubmed-author:SaemundsdottirJonaJ,
pubmed-author:SigurdssonAsgeirA,
pubmed-author:StaceySimon NSN,
pubmed-author:StefanssonKariK,
pubmed-author:SuarezBrian KBK,
pubmed-author:SulemPatrickP,
pubmed-author:SunJielinJ,
pubmed-author:SwinkelsDorine WDW,
pubmed-author:ThorsteinsdottirUnnurU,
pubmed-author:TresAlejandroA,
pubmed-author:WalshPatrick CPC,
pubmed-author:WileyKathleen EKE,
pubmed-author:WitjesJ AlfredJA,
pubmed-author:XuJianfengJ
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
631-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17401366-African Americans,
pubmed-meshheading:17401366-Chromosomes, Human, Pair 8,
pubmed-meshheading:17401366-Europe,
pubmed-meshheading:17401366-European Continental Ancestry Group,
pubmed-meshheading:17401366-Genetic Linkage,
pubmed-meshheading:17401366-Genetic Predisposition to Disease,
pubmed-meshheading:17401366-Genetic Variation,
pubmed-meshheading:17401366-Genomics,
pubmed-meshheading:17401366-Haplotypes,
pubmed-meshheading:17401366-Humans,
pubmed-meshheading:17401366-Male,
pubmed-meshheading:17401366-Polymorphism, Single Nucleotide,
pubmed-meshheading:17401366-Prostatic Neoplasms,
pubmed-meshheading:17401366-United States
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pubmed:year |
2007
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pubmed:articleTitle |
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
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pubmed:affiliation |
deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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