| pubmed-article:1739971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1739971 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1739971 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1739971 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:1739971 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:1739971 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:1739971 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1739971 | pubmed:dateCreated | 1992-3-24 | lld:pubmed |
| pubmed-article:1739971 | pubmed:abstractText | A novel mechanism for inhibition of T cell responses is described. Using the recognition of the influenza hemagglutinin (HA) 307-319 peptide in the context of DR1 class II major histocompatibility complex molecules, we have found that nonstimulatory analogs of the HA peptide preferentially inhibit HA-specific T cells in inhibition of antigen presentation assays. This antigen-specific effect could be generalized to another DR1-restricted peptide, Tetanus toxoid 830-843. Direct binding and cellular experiments indicated that the mechanism responsible was distinct from competition for binding to DR1 molecules. Likewise, negative signaling and induction of T cell tolerance could also be excluded as effector mechanisms. Thus, the most likely mechanism for this effect is engagement of antigen-specific T cell receptors by DR1-peptide analog complexes, which results in antigen-specific competitive blocking of T cell responses by virtue of their capacity to compete with DR1-antigen complexes for binding to the T cell receptor. | lld:pubmed |
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| pubmed-article:1739971 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1739971 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1739971 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1739971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1739971 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1739971 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:AlexanderJJ | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:GreyH MHM | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:AltmanAA | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:CoggeshallMM | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:GaetaF CFC | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:1739971 | pubmed:author | pubmed-author:SettiEE | lld:pubmed |
| pubmed-article:1739971 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1739971 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:1739971 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:1739971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1739971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1739971 | pubmed:pagination | 625-34 | lld:pubmed |
| pubmed-article:1739971 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1739971 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1739971 | pubmed:articleTitle | Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. | lld:pubmed |
| pubmed-article:1739971 | pubmed:affiliation | Cytel, San Diego, California 92121. | lld:pubmed |
| pubmed-article:1739971 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1739971 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1739971 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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