Linked Life Data

17398047

Source:http://linkedlifedata.com/resource/pubmed/id/17398047

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-7-2
pubmed:abstractText
alpha-Lactose monohydrate is an important pharmaceutical excipient used extensively in dry powder inhaler (DPI) formulations. The ways in which a high shear blending process affect this material have been investigated and important process parameters have been identified. Total energy input (kJ/kg), blade design and the conditions in which lactose was stored prior to blending were found to have the most significant effect on the apparent particle size distribution of the processed material, which may subsequently affect the performance of DPI formulations. The power conditions used during blending, equipment temperature and humidity of the headspace above the powder were found to be less important in this respect. Additionally, it was found that high energy blending could induce changes in the water sorption characteristics of the material, although the formation of amorphous material could not be confirmed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0378-5173
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
339
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-90
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The effects of high shear blending on alpha-lactose monohydrate.
pubmed:affiliation
Centre for Formulation Engineering, Department of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, United Kingdom. r.h.bridson@bham.ac.uk
pubmed:publicationType
Journal Article