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rdf:type |
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lifeskim:mentions |
umls-concept:C0015272,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024880,
umls-concept:C0441655,
umls-concept:C1176472,
umls-concept:C1555707,
umls-concept:C1698931,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
3
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pubmed:dateCreated |
2007-4-30
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pubmed:abstractText |
The anti-allergic action of various Oriental medicinal herbs was investigated using in vitro and in vivo experimental models. Of these extracts, the ethanol extract of Meliae cortex (MC) exhibited the most potent activity in mast cells; its IC(50) values were 29+/-1.5 microg/ml for antigen stimulation and 57+/-3.4 microg/ml for thapsigargin stimulation. It inhibited compound-48/80-induced systemic anaphylaxis by 52.9% at a dose of 300 mg/kg in mice; it also inhibited the expression of the proinflammatory mediator TNF-alpha. With regard to its mechanism of action, MC suppressed the activating phosphorylation of Syk, a key enzyme in mast-cell signaling processes and that of Akt in a dose-dependent manner. It also inhibited the MAP kinase ERK1/2, which is critical for the production of inflammatory cytokines in mast cells, as indicated by the suppression of the activating phosphorylation of ERK1/2. Taken together, these results suggest that the anti-allergic activity of MC may be due to the inhibition of histamine secretion and cytokine expression through the Syk inhibition in mast cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Allergic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Syk kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/p-Methoxy-N-methylphenethylamine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-008X
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pubmed:author |
pubmed-author:ChangHyun WookHW,
pubmed-author:ChoiWahn SooWS,
pubmed-author:HANK SKS,
pubmed-author:HanJeung WhanJW,
pubmed-author:KimBo KyungBK,
pubmed-author:KimJie WanJW,
pubmed-author:KimNam WookNW,
pubmed-author:KimYoung MiYM,
pubmed-author:KoNa YoungNY,
pubmed-author:LeeJun HoJH,
pubmed-author:MoonTae ChulTC,
pubmed-author:MunSe HwanSH,
pubmed-author:SeoDong WanDW
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
220
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-34
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:17395225-Anaphylaxis,
pubmed-meshheading:17395225-Animals,
pubmed-meshheading:17395225-Anti-Allergic Agents,
pubmed-meshheading:17395225-Cell Degranulation,
pubmed-meshheading:17395225-Cell Line, Tumor,
pubmed-meshheading:17395225-Cell Survival,
pubmed-meshheading:17395225-Dose-Response Relationship, Drug,
pubmed-meshheading:17395225-Gene Expression,
pubmed-meshheading:17395225-Immunoblotting,
pubmed-meshheading:17395225-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17395225-Male,
pubmed-meshheading:17395225-Mast Cells,
pubmed-meshheading:17395225-Melia azedarach,
pubmed-meshheading:17395225-Mice,
pubmed-meshheading:17395225-Mice, Inbred BALB C,
pubmed-meshheading:17395225-Mice, Inbred ICR,
pubmed-meshheading:17395225-Mitogen-Activated Protein Kinases,
pubmed-meshheading:17395225-Phosphorylation,
pubmed-meshheading:17395225-Plant Extracts,
pubmed-meshheading:17395225-Protein-Tyrosine Kinases,
pubmed-meshheading:17395225-RNA, Messenger,
pubmed-meshheading:17395225-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17395225-Thapsigargin,
pubmed-meshheading:17395225-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17395225-p-Methoxy-N-methylphenethylamine
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pubmed:year |
2007
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pubmed:articleTitle |
Meliae cortex extract exhibits anti-allergic activity through the inhibition of Syk kinase in mast cells.
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pubmed:affiliation |
College of Medicine, Konkuk University, Chungju 380-701, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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