Linked Life Data

17393421

Source:http://linkedlifedata.com/resource/pubmed/id/17393421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-9-4
pubmed:abstractText
Successful embryo implantation and pregnancy in mammals depends on the establishment of immune tolerance between the maternal immune system and fetal cells. Monoclonal nonspecific suppressor factor beta (MNSFbeta), a cytokine produced by suppressor T cells in various tissues, possesses an antigen-nonspecific immune-suppressive function, and may be involved in the regulation of the uterine immune response during embryo implantation. In this study, anti-MNSFbeta IgG administered directly into the uterine lumen, significantly inhibited mouse embryo implantation in a dose-dependent manner in vivo, and this effect was reversed by co-administration of recombinant MNSFbeta. The effects of anti-MNSFbeta IgG on the gene pattern profiles in mouse uterine tissues were examined by cDNA microarray and several changes were confirmed by real-time PCR. Anti-MNSFbeta IgG caused up-regulation (> or = 2-fold) of 71 known genes and 17 unknown genes, and decreased expression (> or = 2-fold) of 74 known genes and 43 unknown genes, including several genes previously associated with embryo implantation or fetal development. Most of the known genes are involved in immune regulation, cell cycle/proliferation, cell differentiation/apoptosis, and lipid/glucose metabolism. These results demonstrate that MNSFbeta plays critical roles during the early pregnancy via multiple pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1040-452X
pubmed:author
pubmed:copyrightInfo
(c) 2007 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1419-27
pubmed:meshHeading
pubmed-meshheading:17393421-Animals, pubmed-meshheading:17393421-Antibodies, pubmed-meshheading:17393421-Antibody Formation, pubmed-meshheading:17393421-Embryo Implantation, pubmed-meshheading:17393421-Endometrium, pubmed-meshheading:17393421-Female, pubmed-meshheading:17393421-Gene Expression Profiling, pubmed-meshheading:17393421-Immunoglobulin G, pubmed-meshheading:17393421-Insects, pubmed-meshheading:17393421-Lipopolysaccharides, pubmed-meshheading:17393421-Mice, pubmed-meshheading:17393421-Mice, Inbred ICR, pubmed-meshheading:17393421-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:17393421-Pregnancy, pubmed-meshheading:17393421-Rabbits, pubmed-meshheading:17393421-Recombinant Proteins, pubmed-meshheading:17393421-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17393421-Suppressor Factors, Immunologic
pubmed:year
2007
pubmed:articleTitle
Immunoneutralization of endometrial monoclonal nonspecific suppressor factor beta (MNSFbeta) inhibits mouse embryo implantation in vivo.
pubmed:affiliation
Key Laboratory of Contraceptives and Devices of National Population and Family Planning Committee, Shanghai Institute of Planned Parenthood Research, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't