Source:http://linkedlifedata.com/resource/pubmed/id/17392730
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-5-16
|
| pubmed:abstractText |
A 5-year-old African-American girl presented with a CYP2D6*4xN/*10 genotype that was discordant with her poor metabolizer phenotype determined with the probe drug dextromethorphan. Both phenotype and genotype were confirmed in repeat assessments, suggesting that the CYP2D6*10 allele carried a novel debilitating sequence variation(s). The rationale for this study was to resolve the discordance and to describe the novel non-functional allelic variant of CYP2D6 and its frequency in populations of different ethnic backgrounds.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0009-9236
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
81
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
817-20
|
| pubmed:meshHeading |
pubmed-meshheading:17392730-African Americans,
pubmed-meshheading:17392730-Child, Preschool,
pubmed-meshheading:17392730-Cytochrome P-450 CYP2D6,
pubmed-meshheading:17392730-Dextromethorphan,
pubmed-meshheading:17392730-Female,
pubmed-meshheading:17392730-Gene Frequency,
pubmed-meshheading:17392730-Genotype,
pubmed-meshheading:17392730-Humans,
pubmed-meshheading:17392730-Molecular Sequence Data,
pubmed-meshheading:17392730-Phenotype
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
|
| pubmed:affiliation |
Section of Developmental Pharmacology and Experimental Therapeutics, Children's Mercy Hospital and Clinics, Kansas City, Missouri, USA. agaedigk@cmh.edu
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|