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rdf:type |
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lifeskim:mentions |
umls-concept:C0036679,
umls-concept:C0039421,
umls-concept:C0205344,
umls-concept:C0237868,
umls-concept:C0332514,
umls-concept:C0567416,
umls-concept:C0677040,
umls-concept:C0680730,
umls-concept:C0920472,
umls-concept:C1148554,
umls-concept:C1547706,
umls-concept:C1999269
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-20
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pubmed:abstractText |
The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drugs in the pharmaceutical industry. This has been due to the rapid increase over the past 10-15 years in potential drug candidates containing one or more asymmetric centers. Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral Technology tools, is provided.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0899-0042
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pubmed:author |
pubmed-author:BachAlvinA2nd,
pubmed-author:BalibarCarlC,
pubmed-author:ByrneNealN,
pubmed-author:CaiYanxuanY,
pubmed-author:CarterGuyG,
pubmed-author:ChlenovMichaelM,
pubmed-author:FanKristiK,
pubmed-author:GoljerIgorI,
pubmed-author:HeYananY,
pubmed-author:HeroldDonD,
pubmed-author:HoDouglasD,
pubmed-author:KaganMichaelM,
pubmed-author:KernsEdwardE,
pubmed-author:KoehnFrankF,
pubmed-author:KramlChristinaC,
pubmed-author:MarathiasVasiliosV,
pubmed-author:MarquezBrianB,
pubmed-author:McConnellOliverO,
pubmed-author:McDonaldLeonardL,
pubmed-author:NogleLisaL,
pubmed-author:OrrR ERE,
pubmed-author:PetucciChristopherC,
pubmed-author:SchlingmannGerhardG,
pubmed-author:SutherlandAlanA,
pubmed-author:TawaGregoryG,
pubmed-author:TischlerMarkM,
pubmed-author:WattsWilliamW,
pubmed-author:WilliamsonR ThomasRT,
pubmed-author:YoungMaireadM,
pubmed-author:ZhangMei-YiMY,
pubmed-author:ZhangYingruY,
pubmed-author:ZhouDahuiD
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
658-82
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pubmed:meshHeading |
pubmed-meshheading:17390370-Chemistry, Pharmaceutical,
pubmed-meshheading:17390370-Chromatography,
pubmed-meshheading:17390370-Circular Dichroism,
pubmed-meshheading:17390370-Drug Design,
pubmed-meshheading:17390370-Drug Industry,
pubmed-meshheading:17390370-Electrons,
pubmed-meshheading:17390370-Humans,
pubmed-meshheading:17390370-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17390370-Models, Chemical,
pubmed-meshheading:17390370-Molecular Conformation,
pubmed-meshheading:17390370-Salts,
pubmed-meshheading:17390370-Stereoisomerism,
pubmed-meshheading:17390370-Technology, Pharmaceutical
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pubmed:year |
2007
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pubmed:articleTitle |
Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.
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pubmed:affiliation |
Wyeth Research, Chemical and Screening Sciences, Collegeville, PA 19426, USA. mcconno@wyeth.com
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pubmed:publicationType |
Journal Article,
Review
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