Linked Life Data

17389490

Source:http://linkedlifedata.com/resource/pubmed/id/17389490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-3-28
pubmed:abstractText
Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1607-14
pubmed:meshHeading
pubmed-meshheading:17389490-Acetylcysteine, pubmed-meshheading:17389490-Animals, pubmed-meshheading:17389490-Antioxidants, pubmed-meshheading:17389490-Apoptosis, pubmed-meshheading:17389490-Blotting, Western, pubmed-meshheading:17389490-COS Cells, pubmed-meshheading:17389490-Cell Culture Techniques, pubmed-meshheading:17389490-Cell Survival, pubmed-meshheading:17389490-Cercopithecus aethiops, pubmed-meshheading:17389490-Chromans, pubmed-meshheading:17389490-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:17389490-Glaucoma, pubmed-meshheading:17389490-HeLa Cells, pubmed-meshheading:17389490-Humans, pubmed-meshheading:17389490-Mutation, pubmed-meshheading:17389490-Oxidative Stress, pubmed-meshheading:17389490-Plasmids, pubmed-meshheading:17389490-Rats, pubmed-meshheading:17389490-Reactive Oxygen Species, pubmed-meshheading:17389490-Retinal Ganglion Cells, pubmed-meshheading:17389490-Transcription Factor TFIIIA, pubmed-meshheading:17389490-Transfection, pubmed-meshheading:17389490-Tumor Necrosis Factor-alpha
pubmed:year
2007
pubmed:articleTitle
A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.
pubmed:affiliation
L.V. Prasad Eye Institute, Hyderabad, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't