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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-20
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pubmed:abstractText |
Osteoblast apoptosis increased in the tibias of apoE(-/-) mice fed with a high-fat diet, decreasing bone formation. The expression of p53 mRNA in marrow adherent cells increased. LDL or oxidized LDL increased apoptosis in the calvarial cells of apoE(-/-) mice. The increase in p53-mediated apoptosis is apparently related to a high-fat diet-induced osteopenia in apoE(-/-) mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1020-30
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pubmed:meshHeading |
pubmed-meshheading:17388726-Alkaline Phosphatase,
pubmed-meshheading:17388726-Animals,
pubmed-meshheading:17388726-Apolipoproteins E,
pubmed-meshheading:17388726-Apoptosis,
pubmed-meshheading:17388726-Biological Markers,
pubmed-meshheading:17388726-Body Weight,
pubmed-meshheading:17388726-Bone Marrow Cells,
pubmed-meshheading:17388726-Collagen Type I,
pubmed-meshheading:17388726-Colony-Forming Units Assay,
pubmed-meshheading:17388726-Dietary Fats,
pubmed-meshheading:17388726-Femur,
pubmed-meshheading:17388726-Fetus,
pubmed-meshheading:17388726-In Situ Nick-End Labeling,
pubmed-meshheading:17388726-Lipids,
pubmed-meshheading:17388726-Lipoproteins, LDL,
pubmed-meshheading:17388726-Male,
pubmed-meshheading:17388726-Mice,
pubmed-meshheading:17388726-Organ Size,
pubmed-meshheading:17388726-Osteoblasts,
pubmed-meshheading:17388726-Osteocalcin,
pubmed-meshheading:17388726-Osteogenesis,
pubmed-meshheading:17388726-RNA, Messenger,
pubmed-meshheading:17388726-Skull,
pubmed-meshheading:17388726-Tumor Suppressor Protein p53,
pubmed-meshheading:17388726-bcl-2-Associated X Protein
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pubmed:year |
2007
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pubmed:articleTitle |
ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells.
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pubmed:affiliation |
Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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pubmed:publicationType |
Journal Article
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