|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001002,
umls-concept:C0003286,
umls-concept:C0022631,
umls-concept:C0034338,
umls-concept:C0050452,
umls-concept:C0072225,
umls-concept:C0072802,
umls-concept:C0205164,
umls-concept:C0259972,
umls-concept:C0441655,
umls-concept:C0851827,
umls-concept:C0870883,
umls-concept:C1701901
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2007-4-17
|
|
pubmed:abstractText |
Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet. The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0013-9580
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
793-800
|
|
pubmed:dateRevised |
2007-11-13
|
|
pubmed:meshHeading |
pubmed-meshheading:17386058-Acetone,
pubmed-meshheading:17386058-Animals,
pubmed-meshheading:17386058-Anticonvulsants,
pubmed-meshheading:17386058-Diet Therapy,
pubmed-meshheading:17386058-Disease Models, Animal,
pubmed-meshheading:17386058-Epilepsy,
pubmed-meshheading:17386058-Ketone Bodies,
pubmed-meshheading:17386058-Malondialdehyde,
pubmed-meshheading:17386058-Mice,
pubmed-meshheading:17386058-Pentylenetetrazole,
pubmed-meshheading:17386058-Pyruvaldehyde,
pubmed-meshheading:17386058-Pyruvic Acid,
pubmed-meshheading:17386058-Seizures
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
|
|
pubmed:affiliation |
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3702, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
|
