Linked Life Data

17385442

Source:http://linkedlifedata.com/resource/pubmed/id/17385442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-27
pubmed:abstractText
To study the regularities in the spread of drug-resistant HIV-1 strains among HIV-infected patients in the Southern Federal District (SFD), the HIV-1 pol gene site encoded for reverse transcriptase was sequenced in the samples taken from 22 HIV-infected SFD patients who received or did not receive antiretroviral therapy (ARVT). Analysis of the primary sequences of the HIV-1 pol gene in SFD patients untreated with antiviral agents revealed the absence of both primary and secondary mutations of resistance to a nucleoside reverse transcriptase inhibitor (NRTI) and a non-nucleoside reverse transcriptase inhibitor (NNRTI). The group of patients receiving antiviral treatment was found to have different drug resistance mutations in the HIV-1 pol gene: K70R, M184V, K219Q, T215Y/F, L74V, etc. Moreover, the patients on ARVT had higher CD4 T lymphocyte levels and higher immunoregulatory index in the presence of significantly lower HIV replication than the untreated patients. The authors make recommendations how to study HIV resistance in patients who are to be treated and are receiving ARVT and advise to monitor the spread of drug-resistant HIV strains in the SFD.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0869-2084
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[Prevalence of mutations of resistance to HIV-I reverse transcriptase inhibitors among HIV-infected patients in the Southern Federal District].
pubmed:publicationType
Journal Article, English Abstract