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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-5-3
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pubmed:abstractText |
XIAP-associated factor 1 (XAF1) negatively regulates the function of the X-linked inhibitor of apoptosis protein (XIAP), a member of the IAP family that exerts antiapoptotic effects. The extracellular signal-regulated kinase (ERK) pathway is thought to increase cell proliferation and to protect cells from apoptosis. The aim of the study was to investigate the correlation between the ERK1/2 signaling pathway and XAF1 in colon cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Butadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/U 0126,
http://linkedlifedata.com/resource/pubmed/chemical/X-Linked Inhibitor of Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/XAF1 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:CaseN BNB,
pubmed-author:HeHuaH,
pubmed-author:KungHsiang FuHF,
pubmed-author:LamS KSK,
pubmed-author:LinMarie C MMC,
pubmed-author:RIBIAA,
pubmed-author:SunYun WeiYW,
pubmed-author:WangJideJ,
pubmed-author:WongBenjamin C YBC,
pubmed-author:WuYun LinYL,
pubmed-author:XiaHarry H XHH,
pubmed-author:YuLi FenLF
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pubmed:copyrightInfo |
(c) 2007 American Cancer Society
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1996-2003
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17385215-Apoptosis,
pubmed-meshheading:17385215-Butadienes,
pubmed-meshheading:17385215-Cell Line, Tumor,
pubmed-meshheading:17385215-Colonic Neoplasms,
pubmed-meshheading:17385215-Dose-Response Relationship, Drug,
pubmed-meshheading:17385215-Down-Regulation,
pubmed-meshheading:17385215-Enzyme Inhibitors,
pubmed-meshheading:17385215-Epidermal Growth Factor,
pubmed-meshheading:17385215-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:17385215-Humans,
pubmed-meshheading:17385215-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17385215-MAP Kinase Kinase 1,
pubmed-meshheading:17385215-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:17385215-Neoplasm Proteins,
pubmed-meshheading:17385215-Nitriles,
pubmed-meshheading:17385215-Phosphorylation,
pubmed-meshheading:17385215-Promoter Regions, Genetic,
pubmed-meshheading:17385215-Transcriptional Activation,
pubmed-meshheading:17385215-Transfection,
pubmed-meshheading:17385215-Up-Regulation,
pubmed-meshheading:17385215-X-Linked Inhibitor of Apoptosis Protein
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pubmed:year |
2007
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pubmed:articleTitle |
XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.
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pubmed:affiliation |
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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