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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-3-26
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pubmed:abstractText |
Angiotensin II (AII) and transforming growth factor-beta (TGF-beta) are closely involved in the pathogenesis of diabetic nephropathy (DN). AII is known to induce TGF-beta production in resident renal cells, including glomerular mesangial cells and tubular epithelial cells. TGF-beta receptor types I and II (TGF-betaRI, II) are up-regulated in the diabetic kidney. The aim of this study was to clarify the role of AII in the regulation of the TGF-beta system in the early stage of DN using AII type1a receptor-deficient(AT1a(-/-)) mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1342-1751
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pubmed:author |
pubmed-author:KashiharaNaokiN,
pubmed-author:MaeshimaYoheiY,
pubmed-author:MakinoHirofumiH,
pubmed-author:MaruyamaKeisukeK,
pubmed-author:OkamotoKazunoriK,
pubmed-author:OkazakiYukoY,
pubmed-author:SatohMinoruM,
pubmed-author:SugayaTakeshiT,
pubmed-author:SugiyamaHitoshiH,
pubmed-author:UchidaHaruhito AHA,
pubmed-author:YamasakiYasushiY
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-87
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pubmed:meshHeading |
pubmed-meshheading:17385003-Angiotensin II,
pubmed-meshheading:17385003-Animals,
pubmed-meshheading:17385003-Diabetes Mellitus, Experimental,
pubmed-meshheading:17385003-Diabetic Nephropathies,
pubmed-meshheading:17385003-Gene Expression,
pubmed-meshheading:17385003-Kidney,
pubmed-meshheading:17385003-Mice,
pubmed-meshheading:17385003-Mice, Inbred C57BL,
pubmed-meshheading:17385003-Mice, Knockout,
pubmed-meshheading:17385003-Receptor, Angiotensin, Type 1,
pubmed-meshheading:17385003-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:17385003-Renin-Angiotensin System,
pubmed-meshheading:17385003-Signal Transduction,
pubmed-meshheading:17385003-Smad Proteins,
pubmed-meshheading:17385003-Transforming Growth Factor beta
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pubmed:year |
2007
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pubmed:articleTitle |
Enhanced TGF-beta/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor.
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pubmed:affiliation |
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. yahman-a-and-y@r5.dion.ne.jp
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pubmed:publicationType |
Journal Article
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