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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-4-10
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pubmed:abstractText |
A qualitative 3D pharmacophore model (a common feature based model or Catalyst HipHop algorithm) was developed for well-known natural product androgen receptor down-regulating agents (ARDAs). The four common chemical features identified included: one hydrophobic group, one ring aromatic group, and two hydrogen bond acceptors. This model served as a template in virtual screening of the Maybridge and NCI databases that resulted in identification of six new ARDAs (EC(50) values 17.5-212 microM). Five of these molecules strongly inhibited the growth of human prostate LNCaP cells. These novel compounds may be used as leads to develop other novel anti-prostate cancer agents.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-10537180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-10773882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-11238180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-11391583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-12032296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-12408714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-12593652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-12773039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-14604672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-14702632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-14754427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-14755679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-14760063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-15013685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-15028253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-15055996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-15078173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-15828836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-15897592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-16170022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-16427289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-16789753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-16821779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17383188-2317815
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3413-21
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17383188-Androgen Antagonists,
pubmed-meshheading:17383188-Androgen Receptor Antagonists,
pubmed-meshheading:17383188-Antineoplastic Agents,
pubmed-meshheading:17383188-Blotting, Western,
pubmed-meshheading:17383188-Catalysis,
pubmed-meshheading:17383188-Cell Line, Tumor,
pubmed-meshheading:17383188-Computational Biology,
pubmed-meshheading:17383188-Databases, Factual,
pubmed-meshheading:17383188-Dose-Response Relationship, Drug,
pubmed-meshheading:17383188-Down-Regulation,
pubmed-meshheading:17383188-Humans,
pubmed-meshheading:17383188-Male,
pubmed-meshheading:17383188-Models, Molecular,
pubmed-meshheading:17383188-Neoplasm Proteins,
pubmed-meshheading:17383188-Prostatic Neoplasms,
pubmed-meshheading:17383188-Structure-Activity Relationship,
pubmed-meshheading:17383188-Tetrazolium Salts,
pubmed-meshheading:17383188-Thiazoles
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pubmed:year |
2007
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pubmed:articleTitle |
First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.
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pubmed:affiliation |
Department of Pharmacology & Experimental Therapeutics, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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