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rdf:type |
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lifeskim:mentions |
umls-concept:C0003069,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205171,
umls-concept:C0225336,
umls-concept:C0301896,
umls-concept:C0337112,
umls-concept:C1135183,
umls-concept:C1415585,
umls-concept:C1524075,
umls-concept:C2709199,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2007-3-26
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pubmed:abstractText |
The susceptibility of porcine endothelial cells (pEC) to human natural killer (NK) cells is related to the failure of human major histocompatibility complex (MHC)-specific killer inhibitory receptors to recognize porcine MHC class I molecules. The aims of this study were (i) to assess the protection of pEC against xenogeneic NK-mediated cytotoxicity afforded by the stable expression of HLA-E single chain trimers (SCT) composed of a canonical HLA-E binding peptide antigen, VMAPRTLIL, the mature human beta2-microglobulin, and the mature HLA-E heavy chain, and (ii) to test whether HLA-E expression on pEC and porcine lymphoblastoid cells affects the adhesion of human NK cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0908-665X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-34
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17381687-Animals,
pubmed-meshheading:17381687-Antibodies, Heterophile,
pubmed-meshheading:17381687-Cell Adhesion,
pubmed-meshheading:17381687-Cell Communication,
pubmed-meshheading:17381687-Cell Line,
pubmed-meshheading:17381687-Cytotoxicity, Immunologic,
pubmed-meshheading:17381687-Endothelium, Vascular,
pubmed-meshheading:17381687-Gene Expression Regulation,
pubmed-meshheading:17381687-HLA Antigens,
pubmed-meshheading:17381687-Histocompatibility Antigens Class I,
pubmed-meshheading:17381687-Humans,
pubmed-meshheading:17381687-Killer Cells, Natural,
pubmed-meshheading:17381687-NK Cell Lectin-Like Receptor Subfamily D,
pubmed-meshheading:17381687-Swine,
pubmed-meshheading:17381687-Transfection,
pubmed-meshheading:17381687-Transgenes,
pubmed-meshheading:17381687-Transplantation, Heterologous
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pubmed:year |
2007
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pubmed:articleTitle |
Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity.
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pubmed:affiliation |
Laboratory for Transplantation Immunology, Department of Internal Medicine, University Hospital Zürich, Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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