Source:http://linkedlifedata.com/resource/pubmed/id/17381501
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2007-5-1
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pubmed:abstractText |
Thioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic dyslipidaemia, since TXNIP is the strongest glucose-responsive gene in pancreatic B-cells, TXNIP deficiency in a mouse model is associated with hyperlipidaemia and TXNIP is located in the 1q21-1q23 chromosomal Type 2 diabetes mellitus (DM) locus. We set out to investigate whether metabolic effects of TXNIP that were previously reported in a murine model are also relevant in human Type 2 DM.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0742-3071
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
498-504
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pubmed:dateRevised |
2007-10-30
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pubmed:meshHeading |
pubmed-meshheading:17381501-Aged,
pubmed-meshheading:17381501-Animals,
pubmed-meshheading:17381501-Blood Glucose,
pubmed-meshheading:17381501-Blood Pressure,
pubmed-meshheading:17381501-Carrier Proteins,
pubmed-meshheading:17381501-Diabetes Mellitus, Type 2,
pubmed-meshheading:17381501-Diabetic Angiopathies,
pubmed-meshheading:17381501-Female,
pubmed-meshheading:17381501-Genetic Predisposition to Disease,
pubmed-meshheading:17381501-Humans,
pubmed-meshheading:17381501-Hypertriglyceridemia,
pubmed-meshheading:17381501-Male,
pubmed-meshheading:17381501-Mice,
pubmed-meshheading:17381501-Middle Aged,
pubmed-meshheading:17381501-Polymorphism, Genetic,
pubmed-meshheading:17381501-Triglycerides
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pubmed:year |
2007
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pubmed:articleTitle |
Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus.
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pubmed:affiliation |
Laboratory of Molecular Metabolism and Endocrinology, Cardiovascular Research Institute Maastricht and Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands. m.vangreevenbroek@intmed.unimaas.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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