Linked Life Data

17380901

Source:http://linkedlifedata.com/resource/pubmed/id/17380901

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-26
pubmed:abstractText
Methionine is an essential amino acid and the universal N-terminal amino acid of proteins. The biosynthesis of methionine is extensively studied in various organisms that could be used in biotechnological production of methionine. Transcriptional regulation of the methionine synthesis in the Corynebacterium glutamicum genome is well studied. The McbR protein is a transcriptional regulator of methionine/cysteine biosynthesis genes. The operon structures for members of the McbR regulon also were predicted. We identified candidate regulatory proteins orthologous to McbR in six additional genomes of the order Actinomycetales. The McbR regulon as well as regulons of the orthologous regulators in related genomes were analyzed using the comparative genomics methods. The obtained data demonstrated multiple and diverse positional rearrangements even in the closest genomes despite early observations of the high level of genome stability in corynebacteria. Moreover, the comparison of the operon structures combined with the regulatory signal analysis allowed us to predict some new potential members of the McbR regulons, such as glutamine amidotransferase and methylthioadenosine nuclease.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-8984
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-50
pubmed:meshHeading
pubmed:articleTitle
[Regulation of methionine/cysteine biosynthesis in Corynebacterium glutamicum and related genomes].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Research Support, Non-U.S. Gov't