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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-23
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pubmed:abstractText |
Pseudomonas aeruginosa showing resistance to imipenem were found in 100 of 1,058 strains (9.5%) from six hospitals (a-f) in Hiroshima City, Japan. Of the 100 strains, 14 (14%) were double disk synergy test positive using sodium mercaptoacetic acid disks, and 18 (18%) were bla(IMP-1) or bla(VIM-2) allele positive by polymerase chain reaction (PCR). Among 100 imipenem-resistant strains, 32 were categorized into multi-drug resistant strains, in which 13 were positive for the metallo-beta-lactamase gene. Fifty-one strains (51%) among the 100 imipenem-resistant strains had elevated RND efflux pump activity against levofloxacin. But only 6 of 51 strains were classified as multi-drug resistant strains. The pulsed field gel electrophoresis analysis of the Spe I-digested DNA from the 100 isolates suggested not only clonal spread but spread of heterogeneous clones started to contribute to the prevalence of metallo-beta-lactamase producing P. aeruginosa strains in Japanese hospitals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0385-5600
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pubmed:author |
pubmed-author:FujiueYoshihiroY,
pubmed-author:GotohNaomasaN,
pubmed-author:HayashidaShizueS,
pubmed-author:ItahaHideyukiH,
pubmed-author:KadonoManamiM,
pubmed-author:KashiyamaSeiyaS,
pubmed-author:KoharaTadahiroT,
pubmed-author:KomatsuzawaHitoshiH,
pubmed-author:KoudaShuntaroS,
pubmed-author:KuwabaraMasaoM,
pubmed-author:OharaMasaruM,
pubmed-author:OnoderaMakotoM,
pubmed-author:SasakiMegumiM,
pubmed-author:SugaiMotoyukiM,
pubmed-author:UsuiTuguruT,
pubmed-author:YokoyamaTakashiT
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-7
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pubmed:meshHeading |
pubmed-meshheading:17380046-Aged,
pubmed-meshheading:17380046-Aged, 80 and over,
pubmed-meshheading:17380046-Anti-Bacterial Agents,
pubmed-meshheading:17380046-Cross Infection,
pubmed-meshheading:17380046-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:17380046-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:17380046-Female,
pubmed-meshheading:17380046-Humans,
pubmed-meshheading:17380046-Imipenem,
pubmed-meshheading:17380046-Japan,
pubmed-meshheading:17380046-Male,
pubmed-meshheading:17380046-Multigene Family,
pubmed-meshheading:17380046-Phylogeny,
pubmed-meshheading:17380046-Pseudomonas Infections,
pubmed-meshheading:17380046-Pseudomonas aeruginosa,
pubmed-meshheading:17380046-beta-Lactam Resistance,
pubmed-meshheading:17380046-beta-Lactamases
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pubmed:year |
2007
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pubmed:articleTitle |
Molecular characterization of imipenem-resistant Pseudomonas aeruginosa in Hiroshima, Japan.
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pubmed:affiliation |
Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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