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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-6-4
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pubmed:abstractText |
Outcomes in patients with brain metastases undergoing whole-brain radiotherapy (WBRT) are hardly encouraging, and an improvement in results is therefore needed. One possible approach is the addition of chemotherapeutics. However the data presented thus far are also disappointing. A promising substance in this setting could become topotecan, which is known to cross the blood-brain barrier and additionally offers radiosensitizing effects. Therefore we performed a phase I/II trial to evaluate the feasibility of a concurrent radiochemotherapy regimen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0360-3016
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pubmed:author |
pubmed-author:GroheChristianC,
pubmed-author:HeddeJan-PeterJP,
pubmed-author:KleinschmidtRolfR,
pubmed-author:KoYon-DschunYD,
pubmed-author:LangeOliverO,
pubmed-author:LosemChristophC,
pubmed-author:MetzlerUteU,
pubmed-author:NeuhausThomasT,
pubmed-author:SchüllerHeinrichH,
pubmed-author:Schmidt-WolfIngo G HIG,
pubmed-author:StierSebastianS
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
68
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
839-44
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pubmed:meshHeading |
pubmed-meshheading:17379446-Adult,
pubmed-meshheading:17379446-Aged,
pubmed-meshheading:17379446-Antineoplastic Agents,
pubmed-meshheading:17379446-Brain Neoplasms,
pubmed-meshheading:17379446-Breast Neoplasms,
pubmed-meshheading:17379446-Dose-Response Relationship, Radiation,
pubmed-meshheading:17379446-Feasibility Studies,
pubmed-meshheading:17379446-Female,
pubmed-meshheading:17379446-Humans,
pubmed-meshheading:17379446-Lung Neoplasms,
pubmed-meshheading:17379446-Male,
pubmed-meshheading:17379446-Middle Aged,
pubmed-meshheading:17379446-Radiation-Sensitizing Agents,
pubmed-meshheading:17379446-Radiotherapy, Adjuvant,
pubmed-meshheading:17379446-Radiotherapy Dosage,
pubmed-meshheading:17379446-Topotecan,
pubmed-meshheading:17379446-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
A phase I/II trial of topotecan and radiation therapy for brain metastases in patients with solid tumors.
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pubmed:affiliation |
Radiological Department, City Hospital of Merheim, Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II,
Clinical Trial, Phase I
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