Linked Life Data

17379241

Source:http://linkedlifedata.com/resource/pubmed/id/17379241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-4-20
pubmed:databankReference
pubmed:abstractText
Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2836
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
368
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1011-23
pubmed:dateRevised
2007-9-14
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.
pubmed:affiliation
International School for Advanced Studies, 34000 Trieste, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't