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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4 Suppl 1
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pubmed:dateCreated |
2007-3-23
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pubmed:abstractText |
Infection of immunocompromised patients with cytomegalovirus (CMV), such as that occurring in patients undergoing hematopoietic stem cell transplantation, is a serious clinical problem. CMV infection has been reported to suppress hematopoiesis. In immunocompetent hosts CMV is controlled initially by the innate immune system, with CD1d molecules and natural killer T (NKT) cells playing a role in the antiviral immune response in several model systems. We hypothesized that CD1d and NKT cells are involved in protection of the hematopoietic modulating effects of CMV, and that adoptive transfer of NKT cells would protect against these infection-induced effects.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-93
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17379092-Adoptive Transfer,
pubmed-meshheading:17379092-Animals,
pubmed-meshheading:17379092-Antigens, CD1,
pubmed-meshheading:17379092-Antigens, CD1d,
pubmed-meshheading:17379092-Cytomegalovirus,
pubmed-meshheading:17379092-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17379092-Herpesviridae Infections,
pubmed-meshheading:17379092-Humans,
pubmed-meshheading:17379092-Immunocompromised Host,
pubmed-meshheading:17379092-Killer Cells, Natural,
pubmed-meshheading:17379092-Mice,
pubmed-meshheading:17379092-Mice, Knockout,
pubmed-meshheading:17379092-Muromegalovirus,
pubmed-meshheading:17379092-Myeloid Progenitor Cells,
pubmed-meshheading:17379092-Myelopoiesis,
pubmed-meshheading:17379092-T-Lymphocytes
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pubmed:year |
2007
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pubmed:articleTitle |
A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus.
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pubmed:affiliation |
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, IN 46202, USA. hbroxmey@iupui.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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