Source:http://linkedlifedata.com/resource/pubmed/id/17377810
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2007-3-22
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| pubmed:abstractText |
Distinguishing between low-grade primary cutaneous B-cell lymphoma (LG-pCBCL) and cutaneous lymphoid hyperplasia (CLH) based on histological features is often difficult. CLH lesions contain numerous reactive cells of the histiocyte lineage [Langerhans cells (LC), dermal dendritic cells (DDC), and macrophages], which are also often present in CBCL. The aim of this study was to determine whether immunohistochemical detection of those cells could help differentiate between CLH and LG-pCBCL. We determined the percentages of those histiocytic cells in the dermal infiltrates of 45 cases of cutaneous lymphoproliferations comprising 16 CLH and 29 LG-pCBCL (19 follicle-center cell lymphomas and 10 marginal zone lymphomas) by immunohistochemical labeling with antibodies to CD1a, FXIIIa, and CD68 to respectively detect LC, DDC, and macrophages. To avoid observer-dependent bias, an automated morphometric analysis method was used to recognize immunoreactive cells and calculate their percentages within the infiltrate. FXIIIa(+) cells were significatively more frequent in CLH than in LG-pCBCL, whereas CD1a(+) and CD68(+) cell frequencies were comparable in the two groups. The results of our study suggest that DDC might play an important role in the genesis of cutaneous lymphomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD1a antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Factor XIIIa
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0945-6317
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
450
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
441-7
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| pubmed:meshHeading |
pubmed-meshheading:17377810-Adolescent,
pubmed-meshheading:17377810-Adult,
pubmed-meshheading:17377810-Aged,
pubmed-meshheading:17377810-Aged, 80 and over,
pubmed-meshheading:17377810-Antigens, CD,
pubmed-meshheading:17377810-Antigens, CD1,
pubmed-meshheading:17377810-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:17377810-Dendritic Cells,
pubmed-meshheading:17377810-Diagnosis, Differential,
pubmed-meshheading:17377810-Factor XIIIa,
pubmed-meshheading:17377810-Female,
pubmed-meshheading:17377810-Humans,
pubmed-meshheading:17377810-Immunohistochemistry,
pubmed-meshheading:17377810-Lymphoma, B-Cell,
pubmed-meshheading:17377810-Male,
pubmed-meshheading:17377810-Middle Aged,
pubmed-meshheading:17377810-Pseudolymphoma,
pubmed-meshheading:17377810-Skin Diseases,
pubmed-meshheading:17377810-Skin Neoplasms
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| pubmed:year |
2007
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| pubmed:articleTitle |
Study of the reactive dendritic cells in small B-cell lymphoproliferations of the skin.
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| pubmed:affiliation |
Département de Pathologie, Hôpital Henri Mondor, VI AP-HP, Université Paris XII, Créteil, France.
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| pubmed:publicationType |
Journal Article
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