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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-3-22
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pubmed:abstractText |
The direct three-component Mannich reactions of O-benzyl hydroxyacetone with p-anisidine and aromatic or aliphatic aldehydes in the presence of an L-threonine-derived catalyst afforded anti-1,2-amino alcohols in good-to-excellent yields and with enantioselectivities of up to 97%. This study is the first demonstration that direct three-component Mannich reactions can be promoted by a primary amino acid in water.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1477-0520
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1018-20
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pubmed:meshHeading |
|
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pubmed:year |
2007
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pubmed:articleTitle |
Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system.
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pubmed:affiliation |
Department of Chemistry, National University of Singapore, Republic of Singapore. chmlyx@nus.edu.sg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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