Source:http://linkedlifedata.com/resource/pubmed/id/17376655
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2007-5-14
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| pubmed:abstractText |
The aim of this study was to examine the effect of cyclooxygenase (COX)-2 on bone response after the placement of implants in the femurs of mice. titanium implants 1.0mm in diameter were placed into the middle of the femurs of 9-week-old male COX-2 wild-type (COX-2(+/+)) and knockout (COX-2(-/-)) mice. For RNA analysis, the mice were killed 0, 1, 2, 4, 7 and 56 days after implantation. RNA was extracted from the bone surrounding the implants. For histological analysis, the mice were killed 4 and 8 weeks after treatment, and undecalcified sections were prepared. Contact microradiography was performed, and the sections were stained with 1% toluidine blue for histological examination. Histomorphometric measurements were obtained with a computer-based image analyser to quantify bone newly formed around the implant and the rate of implant-bone contact. Expression of COX-2 and osteocalcin mRNA was induced in bone surrounding implants in COX-2(+/+) mice, but not in COX-2(-/-) mice. In cortical bone, the implant surface was in direct contact with newly formed bone lamellae in COX-2(+/+) mice; new bone formation was minimal in COX-2(-/-) mice. These results suggest that COX-2 plays an essential role in osseointegration and provide evidence that COX-2-selective non-steroidal anti-inflammatory drugs may interfere with osseointegration clinically.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dental Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Dental Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Titanium,
http://linkedlifedata.com/resource/pubmed/chemical/Tolonium Chloride
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0901-5027
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
36
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
441-6
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| pubmed:meshHeading |
pubmed-meshheading:17376655-Animals,
pubmed-meshheading:17376655-Coloring Agents,
pubmed-meshheading:17376655-Cyclooxygenase 2,
pubmed-meshheading:17376655-Dental Implants,
pubmed-meshheading:17376655-Dental Materials,
pubmed-meshheading:17376655-Femur,
pubmed-meshheading:17376655-Image Processing, Computer-Assisted,
pubmed-meshheading:17376655-Male,
pubmed-meshheading:17376655-Mice,
pubmed-meshheading:17376655-Mice, Inbred C57BL,
pubmed-meshheading:17376655-Mice, Inbred Strains,
pubmed-meshheading:17376655-Mice, Knockout,
pubmed-meshheading:17376655-Microradiography,
pubmed-meshheading:17376655-Osseointegration,
pubmed-meshheading:17376655-Osteocalcin,
pubmed-meshheading:17376655-Osteogenesis,
pubmed-meshheading:17376655-RNA, Messenger,
pubmed-meshheading:17376655-Time Factors,
pubmed-meshheading:17376655-Titanium,
pubmed-meshheading:17376655-Tolonium Chloride
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| pubmed:year |
2007
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| pubmed:articleTitle |
Cyclooxygenase-2 activity is essential for the osseointegration of dental implants.
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| pubmed:affiliation |
Department of Oral-Maxillofacial Surgery, Dentistry and Orthodontics, The University of Tokyo Hospital, Bunkyo, Tokyo, Japan. chikazu-ora@umin.ac.jp <chikazu-ora@umin.ac.jp>
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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