Linked Life Data

17375821

Source:http://linkedlifedata.com/resource/pubmed/id/17375821

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-3-22
pubmed:abstractText
Coded excitation has been successfully used in imaging to increase the signal-to-noise ratio (SNR) and penetration depth. With a contrast agent, wideband signals have been hypothesized to increase the contrast-to-tissue ratio (CTR). However, nonlinear properties of contrast agents make decoding difficult when applying coded excitation to contrast imaging. We propose two chirped excitation methods to image contrast agents, with a mechanical index (MI) ranging from 0.05 to 0.34. In the single chirp method, one chirp is transmitted, followed by a clutter filter to reject tissue echoes, then a matched filter is used to recover range resolution. In the chirp sequence method, an increasing and decreasing chirp sequence is transmitted followed by subtraction of the compressed echoes to reject tissue echoes (assuming tissue is a linear scatterer at low MI). Ten independent acoustic experiments were performed to evaluate the CTR for chirp and tone burst insonation, with the same spatial peak temporal averaged intensity (I(SPTA)). A significant increase in CTR, ranging from 4 dB to 8 dB, is observed for chirped excitation as compared with tone burst insonation, at an I(SPTA) of 0.1 and 0.3 mW/cm2 (P < or = 5e-3). To achieve the same CTR of 15 dB, the spatial peak pulse averaged intensity (I(SPPA)) can be decreased by 6 dB for chirp insonation as compared with tone burst insonation (P < 1e-5). Additionally, an increase of more than 10 dB in tissue rejection ratio (TRR) is observed for a chirp sequence insonation compared to tone burst phase inversion for this set of parameters (P < or = 1e-9). Deconvolution of the linear microbubble response from the received echoes is proposed as a method to recover spatial resolution. The difference in the axial resolution resulting from chirp and three-cycle tone burst insonation is approximately 220 microm. The difference in the mainlobe width between experimental and predicted compressed echoes is less than 20%. The side-lobe amplitude is 9 dB to 16 dB below the mainlobe with a transmitted I(SPTA) from 0.1 to 6.6 mW/cm2.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0885-3010
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
520-9
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Contrast imaging with chirped excitation.
pubmed:affiliation
Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA. ywsun@ucdavis.edu
pubmed:publicationType
Journal Article, Evaluation Studies, Research Support, N.I.H., Extramural