17374995

Source:http://linkedlifedata.com/resource/pubmed/id/17374995

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0031760, umls-concept:C0035304, umls-concept:C0035647, umls-concept:C0087111, umls-concept:C0162638, umls-concept:C0599894
pubmed:issue	6
pubmed:dateCreated	2007-3-29
pubmed:abstractText	Retinal degenerations are the major cause of incurable blindness characterized by loss of retinal photoreceptor cells. Several genes causing these genetic diseases have been identified, however the molecular characterization of a high percentage of patients affected by retinitis pigmentosa (RP), a common form of retinal degeneration, is still unknown. The high genetic heterogeneity of these diseases hampers the comprehension of the pathogenetic mechanism causing photoreceptor cell death. Therapies are not available yet and for this reason there is a lot of interest in understanding the etiology and the pathogenesis of these disorders at a cellular and molecular level. Some common features have been identified in different forms of RP. Apoptosis was reported to be the final outcome in all RP animal models and patients analyzed so far. We recently identified two apoptotic pathways coactivated in photoreceptors undergoing cell death in the retinal degeneration (rd1) mouse model of autosomal recessive RP. Our studies opened new perspectives together with many questions that require deeper analyses in order to take advantage of this knowledge and develop new therapeutic approaches. We believe that minimizing cell demise may represent a promising curing strategy that needs to be exploited for retinal degeneration.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101137841
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1551-4005
pubmed:author	pubmed-author:MarigoValeriaV
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	652-5
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:17374995-Animals, pubmed-meshheading:17374995-Apoptosis, pubmed-meshheading:17374995-Humans, pubmed-meshheading:17374995-Photoreceptor Cells, Vertebrate, pubmed-meshheading:17374995-Retinal Degeneration
pubmed:year	2007
pubmed:articleTitle	Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration.
pubmed:affiliation	Department of Biomedical Sciences, University of Modena and Reggio Emilia, via Campi 287, Modena, Italy. marigo.valeria@unimore.it
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't