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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 4
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pubmed:dateCreated |
2007-3-21
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pubmed:abstractText |
We report that delivery of first-generation replication-deficient adenovirus (RDAd) vectors into primary human fibroblasts is associated with the induction of natural killer (NK) cell-mediated cytolysis in vitro. RDAd vector delivery induced cytolysis by a range of NK cell populations including the NK cell clone NKL, primary polyclonal NK lines and a proportion of NK clones (36 %) in autologous HLA-matched assays. Adenovirus-induced cytolysis was inhibited by antibody blocking of the NK-activating receptor NKG2D, implicating this receptor in this function. NKG2D is ubiquitously expressed on NK cells and CD8(+) T cells. Significantly, gamma-irradiation of the vector eliminated the effect, suggesting that breakthrough expression from the vector induces at least some of the pro-inflammatory responses of unknown aetiology following the application of RDAd vectors during in vivo gene delivery.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17374753-10359122,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1103-8
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:17374753-Adenoviridae,
pubmed-meshheading:17374753-Cells, Cultured,
pubmed-meshheading:17374753-Cytotoxicity, Immunologic,
pubmed-meshheading:17374753-Fibroblasts,
pubmed-meshheading:17374753-Genetic Vectors,
pubmed-meshheading:17374753-Humans,
pubmed-meshheading:17374753-Killer Cells, Natural,
pubmed-meshheading:17374753-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:17374753-Receptors, Immunologic,
pubmed-meshheading:17374753-Receptors, Natural Killer Cell
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pubmed:year |
2007
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pubmed:articleTitle |
Adenovirus vector delivery stimulates natural killer cell recognition.
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pubmed:affiliation |
Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XY, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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