rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010531,
umls-concept:C0030685,
umls-concept:C0377899,
umls-concept:C0391871,
umls-concept:C0441655,
umls-concept:C0442805,
umls-concept:C0596235,
umls-concept:C0680255,
umls-concept:C1167622,
umls-concept:C1283071,
umls-concept:C1510827,
umls-concept:C1963578
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-14
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pubmed:abstractText |
In endocrine cells, IP(3)R (inositol 1,4,5-trisphosphate receptor), a ligand-gated Ca2+ channel, plays an important role in the control of intracellular Ca2+ concentration. There are three subtypes of IP(3)R that are distributed differentially among cell types. RINm5F cells express almost exclusively the IP(3)R-3 subtype. The purpose of the present study was to investigate the effect of PKA (protein kinase A) on the activity of IP(3)R-3 in RINm5F cells.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Carbachol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinergic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1768-322X
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
379-88
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17373911-Animals,
pubmed-meshheading:17373911-Calcium,
pubmed-meshheading:17373911-Carbachol,
pubmed-meshheading:17373911-Cell Line,
pubmed-meshheading:17373911-Cholinergic Agonists,
pubmed-meshheading:17373911-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:17373911-Enzyme Inhibitors,
pubmed-meshheading:17373911-Forskolin,
pubmed-meshheading:17373911-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:17373911-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:17373911-Phosphorylation,
pubmed-meshheading:17373911-RNA, Small Interfering,
pubmed-meshheading:17373911-Rats,
pubmed-meshheading:17373911-Thapsigargin
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pubmed:year |
2007
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pubmed:articleTitle |
Protein kinase A increases the binding affinity and the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor type 3 in RINm5F cells.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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