| pubmed-article:17372910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0242957 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0069515 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0246415 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0520484 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:17372910 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:17372910 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17372910 | pubmed:dateCreated | 2007-5-24 | lld:pubmed |
| pubmed-article:17372910 | pubmed:abstractText | HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras-dependent signaling induced by HER2 receptors. A specific Grb2-SH3 ligand, designed and synthesized in our laboratory, called peptidimer-c, inhibited colony formation in HER2 overexpressing SKBr3 cancer cells. Combined treatment of peptidimer-c with docetaxel further inhibited both colony formation and tumor cell survival compared to docetaxel treatment alone. Efficacy of this combined treatment was correlated with a reduction in the phosphorylation of MAPK and AKT. Finally, peptidimer-c reduced the growth of a HER2(+) human breast cancer (BK111) xenograft in nude mice and potentiated the antitumor effect of docetaxel in a HER2+ hormone-independent human prostate adenocarcinoma (PAC120 HID28) xenograft. These results validate Grb2 as a new target for the HER2 pathway. | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17372910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17372910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17372910 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17372910 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:17372910 | pubmed:author | pubmed-author:PouponMarie-F... | lld:pubmed |
| pubmed-article:17372910 | pubmed:author | pubmed-author:LiuWang-QingW... | lld:pubmed |
| pubmed-article:17372910 | pubmed:author | pubmed-author:VidalMichelM | lld:pubmed |
| pubmed-article:17372910 | pubmed:author | pubmed-author:GarbayChristi... | lld:pubmed |
| pubmed-article:17372910 | pubmed:author | pubmed-author:AssayagFranck... | lld:pubmed |
| pubmed-article:17372910 | pubmed:author | pubmed-author:GrilBrunildeB | lld:pubmed |
| pubmed-article:17372910 | pubmed:copyrightInfo | (c) 2007 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:17372910 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17372910 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17372910 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:17372910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17372910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17372910 | pubmed:pagination | 407-15 | lld:pubmed |
| pubmed-article:17372910 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
| pubmed-article:17372910 | pubmed:meshHeading | pubmed-meshheading:17372910... | lld:pubmed |
