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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-26
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pubmed:abstractText |
Gum arabic, a branched polysaccharide consisting of more than 90% arabinogalactan having a molecular weight around 250,000 Da is the oldest and best known of all natural gums. The objective of the present investigation was to examine whether amphotericin B (AmB), the polyene antibiotic when conjugated to periodate oxidized gum arabic still retained its anti-fungal and anti-leishmanial activity and to evaluate its toxicity and bioavailability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0724-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
971-80
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pubmed:meshHeading |
pubmed-meshheading:17372682-Amphotericin B,
pubmed-meshheading:17372682-Animals,
pubmed-meshheading:17372682-Antifungal Agents,
pubmed-meshheading:17372682-Antiprotozoal Agents,
pubmed-meshheading:17372682-Area Under Curve,
pubmed-meshheading:17372682-Biological Availability,
pubmed-meshheading:17372682-Candida albicans,
pubmed-meshheading:17372682-Chromatography, Gel,
pubmed-meshheading:17372682-Cryptococcus neoformans,
pubmed-meshheading:17372682-Dose-Response Relationship, Drug,
pubmed-meshheading:17372682-Drug Stability,
pubmed-meshheading:17372682-Drug Storage,
pubmed-meshheading:17372682-Female,
pubmed-meshheading:17372682-Gum Arabic,
pubmed-meshheading:17372682-Half-Life,
pubmed-meshheading:17372682-Inhibitory Concentration 50,
pubmed-meshheading:17372682-Leishmania donovani,
pubmed-meshheading:17372682-Models, Chemical,
pubmed-meshheading:17372682-Molecular Structure,
pubmed-meshheading:17372682-Molecular Weight,
pubmed-meshheading:17372682-Rabbits,
pubmed-meshheading:17372682-Solubility
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pubmed:year |
2007
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pubmed:articleTitle |
Amphotericin B-gum arabic conjugates: synthesis, toxicity, bioavailability, and activities against Leishmania and fungi.
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pubmed:affiliation |
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Trivandrum, Kerala, 695 012, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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