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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2007-3-20
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pubmed:abstractText |
The T cell, Ig domain, and mucin domain-1 (TIM-1) gene is associated with Th2 T cell responses and human atopic diseases. The mechanism by which TIM-1 influences T cell responses remains unknown. We demonstrate that TIM-1 is recruited to the TCR-signaling complex via association with CD3. TIM-1 up-regulates TCR-associated signaling events, including phosphorylation of Zap70 and IL-2-inducible T cell kinase. This activity requires TIM-1 tyrosine phosphorylation. TIM-1 expression induces formation of a novel complex that includes PI3K and ITK. Finally, the consequences of TIM-1 activation include increased expression of effector cytokines. These results demonstrate that TIM-1 is a critical component of the human T cell response and provide a mechanistic hypothesis for the role of TIM-1 in disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/HAVCR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP70 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/emt protein-tyrosine kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4342-50
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17371991-Antigens, CD3,
pubmed-meshheading:17371991-Cells, Cultured,
pubmed-meshheading:17371991-Cytokines,
pubmed-meshheading:17371991-Humans,
pubmed-meshheading:17371991-Lymphocyte Activation,
pubmed-meshheading:17371991-Membrane Glycoproteins,
pubmed-meshheading:17371991-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:17371991-Phosphorylation,
pubmed-meshheading:17371991-Protein-Tyrosine Kinases,
pubmed-meshheading:17371991-Receptors, Antigen, T-Cell,
pubmed-meshheading:17371991-Receptors, Virus,
pubmed-meshheading:17371991-T-Lymphocytes,
pubmed-meshheading:17371991-Tyrosine,
pubmed-meshheading:17371991-Up-Regulation,
pubmed-meshheading:17371991-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
2007
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pubmed:articleTitle |
Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals.
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pubmed:affiliation |
Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA.
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pubmed:publicationType |
Journal Article
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