| pubmed-article:17371966 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17371966 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17371966 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:17371966 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:17371966 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17371966 | pubmed:dateCreated | 2007-3-20 | lld:pubmed |
| pubmed-article:17371966 | pubmed:abstractText | In humans, the pathways of memory and effector T cell differentiation remain poorly defined. We have dissected the functional properties of ex vivo effector-memory (EM) CD45RA-CCR7- T lymphocytes present within the circulating CD8+ T cell pool of healthy individuals. Our studies show that EM T cells are heterogeneous and are subdivided based on differential CD27 and CD28 expression into four subsets. EM(1) (CD27+CD28+) and EM(4) (CD27-CD28+) T cells express low levels of effector mediators such as granzyme B and perforin and high levels of CD127/IL-7Ralpha. EM(1) cells also have a relatively short replicative history and display strong ex vivo telomerase activity. Therefore, these cells are closely related to central-memory (CD45RA-CCR7+) cells. In contrast, EM(2) (CD27+CD28-) and EM(3) (CD27-CD28-) cells express mediators characteristic of effector cells, whereby EM(3) cells display stronger ex vivo cytolytic activity and have experienced larger numbers of cell divisions, thus resembling differentiated effector (CD45RA+CCR7-) cells. These data indicate that progressive up-regulation of cytolytic activity and stepwise loss of CCR7, CD28, and CD27 both characterize CD8+ T cell differentiation. Finally, memory CD8+ T cells not only include central-memory cells but also EM(1) cells, which differ in CCR7 expression and may therefore confer memory functions in lymphoid and peripheral tissues, respectively. | lld:pubmed |
| pubmed-article:17371966 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17371966 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17371966 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17371966 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17371966 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17371966 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:ZippeliusAlfr... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:RomeroPedroP | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:SpeiserDaniel... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:PittetMikaël... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:RuferNathalie... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:KurthIsabelI | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:CorthesyPatri... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:TouvreyCédric... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:DevevreEstell... | lld:pubmed |
| pubmed-article:17371966 | pubmed:author | pubmed-author:IancuEmanuela... | lld:pubmed |
| pubmed-article:17371966 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17371966 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17371966 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:17371966 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17371966 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17371966 | pubmed:pagination | 4112-9 | lld:pubmed |
| pubmed-article:17371966 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:17371966 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17371966 | pubmed:articleTitle | Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. | lld:pubmed |
| pubmed-article:17371966 | pubmed:affiliation | Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research-Lausanne Branch, University Hospital of Lausanne, Lausanne, Switzerland. | lld:pubmed |
| pubmed-article:17371966 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17371966 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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