| pubmed-article:17371543 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C0085957 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C0242568 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17371543 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17371543 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17371543 | pubmed:dateCreated | 2007-4-27 | lld:pubmed |
| pubmed-article:17371543 | pubmed:abstractText | Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine has been associated with beneficial effects on overall childhood mortality in low-income countries; this cannot be explained merely by the prevention of tuberculosis (TB) deaths. The beneficial effects of BCG vaccine could be the result of either strengthening of pro-inflammatory mechanisms, helping neonates to fight infections, or the induction of an immune-regulatory network restricting overt inflammation and intense pathology. We aimed to study the effect of live BCG on the ability of dendritic cells (DCs) to polarize T-cell responses. Monocyte-derived DCs were matured in the presence or absence of BCG. The DC phenotype was assessed by CD83 expression, interleukin-12 (IL-12) and IL-10 production, as well as for the ability to polarize T-cell responses. Following stimulation with CD40 ligand, DCs matured in the presence of BCG showed enhanced IL-10 and diminished IL-12 production. These DCs primed naive T cells to develop into IL-10-producing T cells, with no T helper 1 or T helper 2 bias. These results suggest that BCG vaccination might result in the development of IL-10-producing DCs as well as IL-10-producing T cells that could contribute to restricting overt inflammation in infants exposed to pathogens and thus lead to lower infant mortality. | lld:pubmed |
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| pubmed-article:17371543 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17371543 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17371543 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17371543 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17371543 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17371543 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:17371543 | pubmed:author | pubmed-author:AabyPeterP | lld:pubmed |
| pubmed-article:17371543 | pubmed:author | pubmed-author:YazdanbakhshM... | lld:pubmed |
| pubmed-article:17371543 | pubmed:author | pubmed-author:BennChristine... | lld:pubmed |
| pubmed-article:17371543 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:17371543 | pubmed:author | pubmed-author:FillieYvonneY | lld:pubmed |
| pubmed-article:17371543 | pubmed:author | pubmed-author:Madura... | lld:pubmed |
| pubmed-article:17371543 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17371543 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:17371543 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17371543 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17371543 | pubmed:pagination | 276-82 | lld:pubmed |
| pubmed-article:17371543 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17371543 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17371543 | pubmed:articleTitle | BCG stimulated dendritic cells induce an interleukin-10 producing T-cell population with no T helper 1 or T helper 2 bias in vitro. | lld:pubmed |
| pubmed-article:17371543 | pubmed:affiliation | Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. jmlarsen@immi.ku.dk | lld:pubmed |
| pubmed-article:17371543 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17371543 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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