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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-4-27
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pubmed:abstractText |
Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine has been associated with beneficial effects on overall childhood mortality in low-income countries; this cannot be explained merely by the prevention of tuberculosis (TB) deaths. The beneficial effects of BCG vaccine could be the result of either strengthening of pro-inflammatory mechanisms, helping neonates to fight infections, or the induction of an immune-regulatory network restricting overt inflammation and intense pathology. We aimed to study the effect of live BCG on the ability of dendritic cells (DCs) to polarize T-cell responses. Monocyte-derived DCs were matured in the presence or absence of BCG. The DC phenotype was assessed by CD83 expression, interleukin-12 (IL-12) and IL-10 production, as well as for the ability to polarize T-cell responses. Following stimulation with CD40 ligand, DCs matured in the presence of BCG showed enhanced IL-10 and diminished IL-12 production. These DCs primed naive T cells to develop into IL-10-producing T cells, with no T helper 1 or T helper 2 bias. These results suggest that BCG vaccination might result in the development of IL-10-producing DCs as well as IL-10-producing T cells that could contribute to restricting overt inflammation in infants exposed to pathogens and thus lead to lower infant mortality.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-10438968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-10779751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-10837075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-11110734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-11390447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-11529299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-11777990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-11823500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-11861602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12359728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12379697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12385024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12515809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12519306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12706706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12798618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-12913751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-14557547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-14647480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15194836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15240755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15371877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15384045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15516964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15609003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15659474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15729483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15845642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-15981479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-16182604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-16200068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-16200070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-16210638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-16831212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-16878042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-1917252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-8567014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17371543-9338786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17371543-Adult,
pubmed-meshheading:17371543-BCG Vaccine,
pubmed-meshheading:17371543-Cell Communication,
pubmed-meshheading:17371543-Cell Differentiation,
pubmed-meshheading:17371543-Cell Polarity,
pubmed-meshheading:17371543-Cells, Cultured,
pubmed-meshheading:17371543-Coculture Techniques,
pubmed-meshheading:17371543-Dendritic Cells,
pubmed-meshheading:17371543-Humans,
pubmed-meshheading:17371543-Interleukin-10,
pubmed-meshheading:17371543-Interleukin-12,
pubmed-meshheading:17371543-Superantigens,
pubmed-meshheading:17371543-T-Lymphocyte Subsets,
pubmed-meshheading:17371543-Th1 Cells,
pubmed-meshheading:17371543-Th2 Cells
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pubmed:year |
2007
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pubmed:articleTitle |
BCG stimulated dendritic cells induce an interleukin-10 producing T-cell population with no T helper 1 or T helper 2 bias in vitro.
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pubmed:affiliation |
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. jmlarsen@immi.ku.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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